Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis

被引：35

作者：

Sakamoto, Noriho ^{[1
]}

Ishimoto, Hiroshi ^{[1
]}

Nakashima, Shota ^{[1
]}

Yura, Hirokazu ^{[1
]}

Miyamura, Takuto ^{[1
]}

Okuno, Daisuke ^{[1
]}

Hara, Atsuko ^{[1
]}

Kitazaki, Takeshi ^{[2
]}

Kakugawa, Tomoyuki ^{[1
]}

Ishimatsu, Yuji ^{[3
]}

Satoh, Minoru ^{[4
]}

Mukae, Hiroshi ^{[1
]}

机构：

[1] Nagasaki Univ, Dept Resp Med, Sch Biomed Sci, Nagasaki, Japan

[2] Japanese Red Cross Nagasaki Genbaku Hosp, Dept Resp Med, Nagasaki, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Unit Rehabil Sci, Dept Cardiopulm Rehabil Sci, Nagasaki, Japan

[4] Univ Occupat & Environm Hlth, Sch Hlth Sci, Dept Clin Nursing, Kitakyushu, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2019年 / 58卷 / 06期

关键词：

acute interstitial pneumonia; anti-melanoma differentiation-associated gene 5; clinically amyopathic dermatomyositis; AMYOPATHIC DERMATOMYOSITIS; JAPANESE PATIENTS; AUTOANTIBODIES;

D O I：

10.2169/internalmedicine.1516-18

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. All patients succumbed to respiratory failure within two months. Anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM should be included in the differential diagnosis of acute/subacute ILD. Measurement of anti-MDA5 antibody and an intensive immunosuppressive regimen might rescue these patients from RP-ILD.

引用

页码：837 / 841

页数：5

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