New Spectrophotometric Method for Simultaneous determination of Metoprolol Tartarate and Hydrochlorthiazide in Tablets

被引：8

作者：

Gupta, K. R. ^{[1
]}

Tajne, M. R. ^{[1
]}

Wadodkar, S. G. ^{[2
]}

机构：

[1] RTM Nagpur Univ, Dept Pharmaceut Sci, Nagpur 33, Maharashtra, India

[2] SKB Coll Pharm, New Kamptee 441002, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 70卷 / 04期

关键词：

Hydrochlothiazide; metoprolol tartrate; spectrophotometry; two wavelength method;

D O I：

10.4103/0250-474X.44606

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present work describes a two-wavelength method for simultaneous determination of metoprolol and hydrochlorthiazide in fixed dose combination tablet. The wavelengths selected for method were 257.8 nm, 282.9 nm and 315.0 nm. The absorbance difference at first two wavelengths was used for determination of metoprolol and the latter was used for determination of hydrochlorthiazide. The recovery value for the drugs from the tablet matrix was found to be 100.55% (metoprolol) and 99.97% (comparison with standard) and 98.09% (EM, 1cm) for hydrochlorthiazide. The method has an advantage that hydrochlorthiazide can be estimated in combination, as there is no interference of metoprolol at 315.0 nm. The method was evaluated statistically for its accuracy and precision.

引用

页码：511 / 513

页数：3

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