Antidermatophytic activity of extracts from Psoralea corylifolia (Fabaceae) correlated with the presence of a flavonoid compound

被引：58

作者：

Prasad, NR

Anandi, C

Balasubramanian, S

Pugalendi, KV ^{[1
]}

机构：

[1] Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India

[2] Annamalai Univ, Dept Microbiol, RMMC&H, Annamalainagar 608002, Tamil Nadu, India

[3] Annamalai Univ, Dept Chem, Annamalainagar 608002, Tamil Nadu, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 91卷 / 01期

关键词：

antidermatophytic activity; Psoralea corylifolia; flavonoid; plant extracts;

D O I：

10.1016/j.jep.2003.11.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extracts obtained from seeds of Psoralea corylifolia showed several degrees of antifungal activity against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsportan gypseum by the disc diffusion method on a Sabouraud dextrose agar (SDA) medium. Methanol extract of the seeds at 250 mug exhibited the maximum inhibition with a halo of 28 mm diameter. Six different bands were obtained when the methanol extract was subjected to TLC. C-13 NMR and Mass spectra revealed that the active compound would be a flavonoid, 4'-methoxy flavone. MIC of the active compound along with standard miconazole was carried out using tube dilution technique. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：21 / 24

页数：4

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