Puberty and bone development

被引：116
|
作者：
Saggese, G
Baroncelli, GI
Bertelloni, S
机构：
[1] Univ Pisa, Dept Reprod Med & Pediat, Div Paediat, I-56125 Pisa, Italy
[2] Univ Pisa, Dept Reprod Med & Pediat, Div Pediat, Endocrine Unit, I-56125 Pisa, Italy
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2002年 / 16卷 / 01期
关键词：
bone mass; bone mineral density; bone strength; bone turnover; calcium; fracture; hormones; menarche; muscle mass; muscle strength; puberty; vitamin D;
D O I：
10.1053/beem.2001.0180
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Puberty has a key role for bone development. Skeletal mass approximately doubles at the end of adolescence. The main determinants of pubertal gain of bone mass are the sex steroids, growth hormone and insulin-like growth factors (by their effects on bone and muscle mass), 1,25-dihydroxyvitamin D (by stimulating calcium absorption and retention) and muscle mass (by regulating modelling/remodelling thresholds). Calcium intake is an additional factor influencing bone formation. The interactions among these factors are undefined. The accrual of bone mass during puberty is a major determinant of peak bone mass and, thereby, of the risk of osteoporotic fractures during advanced age.
引用
收藏
页码：53 / 64
页数：12
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