bone mass;
bone mineral density;
bone strength;
bone turnover;
calcium;
fracture;
hormones;
menarche;
muscle mass;
muscle strength;
puberty;
vitamin D;
D O I:
10.1053/beem.2001.0180
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Puberty has a key role for bone development. Skeletal mass approximately doubles at the end of adolescence. The main determinants of pubertal gain of bone mass are the sex steroids, growth hormone and insulin-like growth factors (by their effects on bone and muscle mass), 1,25-dihydroxyvitamin D (by stimulating calcium absorption and retention) and muscle mass (by regulating modelling/remodelling thresholds). Calcium intake is an additional factor influencing bone formation. The interactions among these factors are undefined. The accrual of bone mass during puberty is a major determinant of peak bone mass and, thereby, of the risk of osteoporotic fractures during advanced age.
机构:
Royal Manchester Childrens Hosp, Dept Paediat Endocrinol, Manchester M13 9WL, Lancs, EnglandRoyal Manchester Childrens Hosp, Dept Paediat Endocrinol, Manchester M13 9WL, Lancs, England
Mughal, Mohamed Z.
Khadilkar, Anuradha V.
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h-index: 0
机构:
Hirabai Cowasji Jehangir Med Res Inst, Pune, Maharashtra, IndiaRoyal Manchester Childrens Hosp, Dept Paediat Endocrinol, Manchester M13 9WL, Lancs, England
机构:
Childrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Univ Penn, Dept Genet, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Cousminer, Diana L.
Mitchell, Jonathan A.
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h-index: 0
机构:
Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA 19104 USA
Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Mitchell, Jonathan A.
Chesi, Alessandra
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机构:
Childrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Chesi, Alessandra
Roy, Sani M.
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h-index: 0
机构:
Cook Childrens Med Ctr, Div Endocrinol & Diabet, Ft Worth, TX USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Roy, Sani M.
Kalkwarf, Heidi J.
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h-index: 0
机构:
Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Kalkwarf, Heidi J.
Lappe, Joan M.
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h-index: 0
机构:
Creighton Univ, Dept Med, Div Endocrinol, Omaha, NE 68178 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Lappe, Joan M.
Gilsanz, Vicente
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h-index: 0
机构:
Childrens Hosp Los Angeles, Dept Radiol, Los Angeles, CA 90027 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Gilsanz, Vicente
Oberfield, Sharon E.
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h-index: 0
机构:
Columbia Univ, Dept Pediat, Med Ctr, Div Pediat Endocrinol Diabet & Metab, New York, NY 10027 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Oberfield, Sharon E.
Shepherd, John A.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Shepherd, John A.
Kelly, Andrea
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h-index: 0
机构:
Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Div Endocrinol & Diabet, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Kelly, Andrea
McCormack, Shana E.
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h-index: 0
机构:
Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Div Endocrinol & Diabet, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
McCormack, Shana E.
Voight, Benjamin F.
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h-index: 0
机构:
Univ Penn, Dept Genet, Philadelphia, PA 19104 USA
Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA
Univ Penn, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Voight, Benjamin F.
Zemel, Babette S.
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h-index: 0
机构:
Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA 19104 USA
Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Zemel, Babette S.
Grant, Struan F. A.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA
Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Div Endocrinol & Diabet, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Human Genet, 2615 Civ Ctr Blvd,Room 1103F, Philadelphia, PA 19104 USA