Synthesis, structures, and Helicobacter Pylori urease inhibition of hydroxamate-coordinated oxovanadium complexes with benzohydrazone ligands

被引：29

作者：

Cheng, Xiao-Shan ^{[1
]}

Zhang, Ji-Cai ^{[1
]}

You, Zhong-Lu ^{[1
,2
]}

Wang, Xue ^{[1
]}

Li, Hai-Hua ^{[1
]}

机构：

[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Peoples R China

[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

TRANSITION METAL CHEMISTRY | 2014年 / 39卷 / 03期

关键词：

BINDING INHIBITORS; IN-VITRO; DERIVATIVES; ACIDS;

D O I：

10.1007/s11243-014-9802-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new acetohydroxamate-coordinated oxovanadium(V) complex, [VOL(AE)] (1), and a new benzohydroxamate-coordinated oxovanadium(V) complex, [VOL(BE)] (2), where L is the dianionic form of N'-(2-hydroxy-5-methylbenzylidene)-2-methoxybenzohydrazide, have been synthesized and characterized by physicochemical methods and single-crystal X-ray diffraction. The V atom in each complex adopts octahedral coordination. Thermal stabilities and urease inhibitory activities of the complexes were studied. The percent inhibition of complexes 1 and 2 at the concentration of 100 mu mol L-1 on Helicobacter pylori urease is 81.2 and 46.7 %, respectively. Complex 1 has an IC50 value of 27.0 mu mol L-1. A molecular docking study of the complexes with the H. pylori urease was performed.

引用

页码：291 / 297

页数：7

共 24 条

[1] Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors [J].

Aslam, Muhammad Adil S. ;

Mahmood, Shams-ul ;

Shahid, Mohammad ;

Saeed, Aamer ;

Iqbal, Jamshed .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (11) :5473-5479

[2] Synthesis, biological activity and docking study of some new isatin Schiff base derivatives [J].

Azizian, Javad ;

Mohammadi, Mohammad K. ;

Firuzi, Omidreza ;

Razzaghi-asl, Nima ;

Miri, Ramin .

MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (11) :3730-3740

[3] Hydroxamic Acids Designed as Inhibitors of Urease [J].

Barros, Thalita G. ;

Williamson, John S. ;

Antunes, O. A. C. ;

Muri, Estela M. F. .

LETTERS IN DRUG DESIGN & DISCOVERY, 2009, 6 (03) :186-192

[4]

Bruker, 1998, SMART VERS 5 628 SAI

[5]

Caravan P, 1995, J AM CHEM SOC, V117, P12759

[6] USE OF CONDUCTIVITY MEASUREMENTS IN ORGANIC SOLVENTS FOR CHARACTERISATION OF COORDINATION COMPOUNDS [J].

GEARY, WJ .

COORDINATION CHEMISTRY REVIEWS, 1971, 7 (01) :81-&

[7] Inhibition of chitosan-immobilized urease by slow-binding inhibitors:: Ni2+, F- and acetohydroxamic acid [J].

Krajewska, B ;

Zaborska, W ;

Leszko, M .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2001, 14 (4-6) :101-109

[8] Jack bean urease: The effect of active-site binding inhibitors on the reactivity of enzyme thiol groups [J].

Krajewska, Barbara ;

Zaborska, Wieslawa .

BIOORGANIC CHEMISTRY, 2007, 35 (05) :355-365

[9]

Kumar S, 2010, MED CHEM RES, V19, pS113

[10] Metal complexes as enzyme inhibitors [J].

Louie, AY ;

Meade, TJ .

CHEMICAL REVIEWS, 1999, 99 (09) :2711-2734

← 1 2 3 →