The role of glioma stem cells in glioma tumorigenesis

被引：16
|
作者：
Yin, Chang-lin [1 ]
Lv, Sheng-qing [2 ]
Chen, Xiang-yu [1 ]
Guo, Hao [1 ]
机构：
[1] Third Mil Med Univ, Southwest Hosp, Dept Emergency, Chongqing 400038, Peoples R China
[2] Third Mil Med Univ, Xinqiao Hosp, Dept Neurosurg, Chongqing 400037, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2014年 / 19卷
关键词：
central nervous system; Glioma stem cells; neural stem cells; Review; TUMOR ANGIOGENESIS; INITIATING CELLS; GROWTH; DIFFERENTIATION; EXPRESSION; P53; IDENTIFICATION; ACTIVATION; HIERARCHY; RECEPTOR;
D O I：
10.2741/4249
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Malignant gliomas, the most common type of primary brain tumor, account for 80% of malignant tumors in the central nervous system (CNS). There are three principal types of glioma: astrocytomas, oligodendrogliomas, and oligoastrocytomas. Glioma stem cells (GSCs) have been found in all types; however, many fundamental questions about GSCs remain unanswered. This review will examine the current state of knowledge regarding GSC origin and the signaling pathways implicated in GSC tumorigenesis. The outstanding challenges for the study of GSCs in the context of glioma progression will also be discussed.
引用
收藏
页码：818 / 823
页数：6
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