Synthesis and biodistribution of a novel 99mTc nitrido radiopharmaceutical with proline dithiocarbamate as a potential tumor imaging agent

被引：11

作者：

Liu, Miao ^{[1
]}

Lin, Xiao ^{[1
]}

Song, Xiaoqing ^{[1
]}

Cui, Yang ^{[1
]}

Li, Peiwen ^{[1
]}

Wang, Xuebin ^{[1
]}

Zhang, Junbo ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2013年 / 298卷 / 03期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Tumor imaging; L-proline; Dithiocarbamate; (TcN)-Tc-99m](2+) core; AMINO-ACID; TYROSINE; PET; CARBON-11-METHIONINE; COMPLEX;

D O I：

10.1007/s10967-013-2592-x

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In the present study, proline dithiocarbamate (PRODTC) ligand was radiolabeled with the [(99m)Tca parts per thousand N](2+) core successfully to obtain the (TcN)-Tc-99m-PRODTC complex with high radiochemical purity. No decomposition of the complex at room temperature was observed over a period of 6 h. Its partition coefficient indicated that it was a hydrophilic complex. The electrophoresis results showed that the complex was negative. The biodistribution of (TcN)-Tc-99m-PRODTC in mice bearing S 180 tumor showed that the complex accumulated in the tumor with a certain uptake. The tumor/blood and tumor/muscle ratios reached 2.19 and 4.54 at 2 h post-injection, suggesting it would be a promising candidate for tumor imaging.

引用

页码：1659 / 1663

页数：5

共 20 条

[1] Unique chemistry of amino acid dithiocarbamates with Ru(III) bis-β-diketonates [J].