Genetic predisposition to prostate cancer

被引：1

作者：

Jeanteur, Philippe ^{[1
,2
]}

机构：

[1] Inst Genet Mol Montpellier, CNRS, UMR 5535, F-34293 Montpellier 05, France

[2] Inst Genet Mol Montpellier, IFR 122, F-34293 Montpellier 05, France

来源：

BULLETIN DU CANCER | 2008年 / 95卷 / 11期

关键词：

genetic predisposition; prostate cancer;

D O I：

10.1684/bdc.2008.0741

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The advent and recent use of Genome-Wide Association studies (GWAS) for the search of genetic predisposition markers for prostate cancer since 2006 has put a very strong emphasis on the 8q24 locus where several single nucleotide polymorphisms (SNP) have been significantly associated with an increased relative risk. A wealth of recent papers have all confirmed the interest of this locus and identified several others. Interestingly, these markers seem to have additive effects pointing to the high complexity of prostate cancer predisposition. This situation along with out-current inability to identify any causal gene(s) in these regions make these findings difficult to translate into routine clinical practice at the present time, a fortiori in terms of population screening.

引用

页码：1063 / 1066

页数：4

共 29 条

[1] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[2]

[Anonymous], CANC FACTS FIG 2003

[3]

Bénard J, 2006, B CANCER, V93, P5

[4]

Bova GS, 1996, WORLD J UROL, V14, P338

[5] Molecular aspects of prostate cancer: recent data from the literature [J].

Camparo, Philippe ;

Vieillefond, Annick .

BULLETIN DU CANCER, 2007, 94 :F77-F88

[6] Epidemiology of prostate cancer [J].

Crawford, ED .

UROLOGY, 2003, 62 (6A) :3-12

[7] Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: The hidden face of estrogens [J].

Cussenot, Olivier ;

Azzouzi, Abdel Rhamene ;

Nicolaiew, Nathalie ;

Fromont, Gaelle ;

Mangin, Philippe ;

Cormier, Luc ;

Fournier, Georges ;

Valeri, Antoine ;

Larre, Stephane ;

Thibault, Frederic ;

Giordanella, Jean-Pierre ;

Pouchard, Michel ;

Zheng, Yan ;

Hamdy, Freddie C. ;

Cox, Angela ;

Cancel-Tassin, Geraldine .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (24) :3596-3602

[8] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[9] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[10] Complexities of prostate-cancer risk [J].

Gelmann, Edward P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (09) :961-963

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