Association of physical activity, body mass index and reproductive history with breast cancer by menopausal status in Iranian women

被引:7
作者
Maleki, Farzad [1 ,2 ]
Fotouhi, Akbar [3 ]
Ghiasvand, Reza [4 ,5 ]
Harirchi, Iraj [2 ]
Talebi, Ghazaleh [2 ]
Rostami, Sahar [2 ,6 ]
Hosseini, Mostafa [3 ]
Rozek, Laura [7 ]
Zendehdel, Kazem [2 ,8 ,9 ]
机构
[1] Urmia Univ Med Sci, Social Determinants Hlth Res Ctr, Orumiyeh, Iran
[2] Univ Tehran Med Sci, Canc Inst Iran, Canc Res Ctr, Tehran, Iran
[3] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran
[4] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol, Oslo, Norway
[5] Canc Registry Norway, Dept Res, Oslo, Norway
[6] Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran
[7] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
[8] Univ Tehran Med Sci, Canc Inst Iran, Breast Dis Res Ctr, Tehran 1314158, Iran
[9] Univ Tehran Med Sci, Canc Inst Iran, Canc Biol Res Ctr, Tehran, Iran
关键词
Breast neoplasms; Exercise; Body mass index; Reproductive histor; Menopause; HORMONE REPLACEMENT THERAPY; SEDENTARY BEHAVIOR; TEHRANIAN ADULTS; RISK; MENARCHE; OBESITY; AGE; TRENDS; PREMENOPAUSAL; PREVALENCE;
D O I
10.1016/j.canep.2020.101738
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The incidence rate of breast cancer (BC) is increasing in low- and middle-income countries (LMICs), including Iran. We investigated the association between BC risk and physical activity (PA), body mass index (BMI), and reproductive history among Iranian women. Methods: We conducted a large hospital-based case-control study and compared 958 BC cases with 967 controls at the Cancer Institute of Iran during 2011-2016. We used multiple logistic regression models and adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for the associations between BC and different risk factors, including low physical activity. Results: Women with high levels of physical activity had a lower risk of BC compared to those who were inactive (OR = 0.55, 95%CI: 0.41, 0.75). In premenopausal women, the association was observed only in normal-weight women (OR = 0.31, 95%CI: 0.13, 0.75), while it was limited to obese women in the postmenopausal group (OR = 0.29, 95%CI: 0.12, 0.66). We found a high risk of postmenopausal BC among overweight (OR = 1.69; 95%CI: 1.01, 2.81) and obese women (OR = 1.9; 95%CI: 1.14, 3.14) compared to women with a normal BMI. We observed an inverse association among postmenopausal women who had between three and five children (OR = 0.31, 95%CI 0.14, 0.64) and more than six children (OR = 0.21, 95%CI 0.12, 0.42) compared to nulliparous women. Conclusions: Low levels of physical activity, low parity, and being overweight or obese were major risk factors for BC. For the first time, we report a strong association between physical activity and BC risk in Iranian women.
引用
收藏
页数:9
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