A rare case of primary pleomorphic liposarcoma of the liver in an 8-year-old female German shepherd dog is described. The liver turnout, measuring 10x12x5 cm, was located in the right hepatic lobe. The diagnosis of pleomorphic liposarcoma was based on the morphological and immunohistochemical features of the turnout cells. To our knowledge, this is the second case of primary liposarcoma of the liver in the dog found in the veterinary literature.