Clinical implications of serum Wisteria floribunda agglutinin-positive Mac-2-binding protein in treatment-naive chronic hepatitis B

被引：30

作者：

Ishii, Akio ^{[1
]}

Nishikawa, Hiroki ^{[1
]}

Enomoto, Hirayuki ^{[1
]}

Iwata, Yoshinori ^{[1
]}

Kishino, Kyohei ^{[1
]}

Shimono, Yoshihiro ^{[1
]}

Hasegawa, Kunihiro ^{[1
]}

Nakano, Chikage ^{[1
]}

Takata, Ryo ^{[1
]}

Nishimura, Takashi ^{[1
]}

Yoh, Kazunori ^{[1
]}

Aizawa, Nobuhiro ^{[1
]}

Sakai, Yoshiyuki ^{[1
]}

Ikeda, Naoto ^{[1
]}

Takashima, Tomoyuki ^{[1
]}

Iijima, Hiroko ^{[1
]}

Nishiguchi, Shuhei ^{[1
]}

机构：

[1] Hyogo Coll Med, Dept Internal Med, Div Hepatobiliary & Pancreat Dis, 1-1 Mukogawacho, Nishinomiya, Hyogo 6638501, Japan

来源：

HEPATOLOGY RESEARCH | 2017年 / 47卷 / 02期

关键词：

chronic hepatitis b; inflammation activity; liver fibrosis; serum marker; Wisteria floribunda agglutinin-positive Mac-2-binding protein; MAC-2; BINDING-PROTEIN; SIMPLE NONINVASIVE INDEX; LIVER FIBROSIS; HEPATOCELLULAR-CARCINOMA; VIRUS; CIRRHOSIS; PREDICT; MARKER; INFECTION; THERAPY;

D O I：

10.1111/hepr.12703

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimTo examine the relationship between serum Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA(+)-M2BP) levels and liver histological findings for patients with treatment naive chronic hepatitis B (CHB). MethodsA total of 189 treatment naive-CHB patients were analyzed. We examined the effect of pretreatment serum WFA(+)-M2BP levels on histological findings compared with other laboratory markers, including aspartate aminotransferase (AST) to platelet ratio index, Fibrosis-4 index, platelet count, AST to alanine aminotransferase (ALT) ratio, and hyaluronic acid as liver fibrosis markers, and AST value, ALT value, and serum interferon--inducible protein-10 level as liver inflammation markers. ResultsThe WFA(+)-M2BP value ranged from 0.3 cut-off index (COI) to 12.9 COI (median value, 1.2 COI). The degree of liver fibrosis was significantly stratified according to WFA(+)-M2BP level in each group except for groups F2 and F3 and the degree of liver inflammation activity was significantly stratified according to WFA(+)-M2BP level in each group. For predicting F4, WFA(+)-M2BP level yielded the highest area under the receiver operating characteristic curve (AUROC) with a level of 0.87 and for predicting advanced liver fibrosis (F3) and significant liver fibrosis (F2), WFA(+)-M2BP level yielded the second highest AUROCs (both, 0.77) among six fibrotic markers. For predicting severe (A3) or significant liver inflammation activity (A2), AUROCs of WFA(+)-M2BP level were 0.78 and 0.76. ConclusionThe WFA(+)-M2BP level can be a useful marker for assessing liver histological findings in patients with treatment-naive CHB, although it has several limitations.

引用

页码：204 / 215

页数：12

共 35 条

[21] Clinical significance of serum Wisteria floribunda agglutinin positive Mac-2-binding protein level and high-sensitivity C-reactive protein concentration in autoimmune hepatitis [J].