Synthesis and antimicrobial evaluation of carbohydrate and polyhydroxylated non-carbohydrate fatty acid ester and ether derivatives

被引：55

作者：

Smith, Aoife ^{[1
]}

Nobmann, Patricia ^{[1
]}

Henehan, Gary ^{[1
]}

Bourke, Paula ^{[1
]}

Dunne, Julie ^{[1
]}

机构：

[1] Dublin Inst Technol, Sch Food Sci & Environm Hlth, Dublin 1, Ireland

来源：

CARBOHYDRATE RESEARCH | 2008年 / 343卷 / 15期

关键词：

Fatty acid derivatives; Lauric acid; Monolaurin; Antimicrobial activity; Staphylococcus aureus; Escherichia coli;

D O I：

10.1016/j.carres.2008.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of fatty acid ester and ether derivatives have been chemically synthesised based on carbohydrate and non-carbohydrate polyhydroxylated scaffolds. The synthesised compounds, along with their corresponding fatty acid monoglyceride antimicrobials, were evaluated for antimicrobial activity against Staphylococcus aureus and Escherichia coli. Of the derivatives synthesised, several Of the Carbohydrate-based compounds have antimicrobial efficacy comparable with commercially available antimicrobials. The results suggest that the nature of the carbohydrate core plays a role in the efficacy of carbohydrate fatty acid derivatives as antimicrobials. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2557 / 2566

页数：10

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