Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis

被引：61

作者：

Geng, Ming ^{[1
]}

Xin, Xuan ^{[1
]}

Bi, Li-Quan ^{[1
]}

Zhou, Lu-Ting ^{[1
]}

Liu, Xiao-Hong ^{[1
]}

机构：

[1] Jinan Mil Command, Gen Hosp, Dept Pathol, Shifang Rd 25, Jinan 250031, Shandong, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2015年 / 21卷 / 38期

基金：

美国国家科学基金会;

关键词：

Hepatocellular carcinoma; Hepatitis B virus; Hepatitis B virus X protein; Hepatocarcinogenesis; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA; CORE PROMOTER; SIGNALING PATHWAY; UP-REGULATION; HBX MUTANTS; CELL-PROLIFERATION; NONCODING RNAS; LIVER-CELLS; MUTATIONS;

D O I：

10.3748/wjg.v21.i38.10732

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Many factors are considered to contribute to hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signaling pathways associated with cell proliferation and invasion, and HBx C-terminal truncation has been suggested to impact the development of HCC. This review focuses on the pathological functions of HBx in HBV-induced hepatocarcinogenesis. As a transactivator, HBx can affect regulatory non-coding RNAs (ncRNAs), including microRNAs and long ncRNAs. HBx is also involved in epigenetic modification and DNA repair. HBx interacts with various signal-transduction pathways, such as the p53, Wnt, and nuclear factor-kappa B pathways. We conclude that HBx hastens the development of hepatoma.

引用

页码：10732 / 10738

页数：7

共 65 条

[1] Tumor suppressor micro RNA miR-145 and onco micro RNAs miR-21 and miR-222 expressions are differentially modulated by Hepatitis B virus X protein in malignant hepatocytes [J].

Bandopadhyay, Manikankana ;

Banerjee, Arup ;

Sarkar, Neelakshi ;

Panigrahi, Rajesh ;

Datta, Sibnarayan ;

Pal, Ananya ;

Singh, Shivram Prasad ;

Biswas, Avik ;

Chakrabarti, Shekhar ;

Chakravarty, Runu .

BMC CANCER, 2014, 14

[2] High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers [J].

Baptista, M ;

Kramvis, A ;

Kew, MC .

HEPATOLOGY, 1999, 29 (03) :946-953

[3] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[4]

Bi LQ, 2014, INT J CLIN EXP PATHO, V7, P987

[5] Hepatitis B virus X-protein binds damaged DNA and sensitizes liver cells to ultraviolet irradiation [J].

Capovilla, A ;

Carmona, S ;

Arbuthnot, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 232 (01) :255-260

[6] Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level [J].

Chen, CJ ;

Yang, HI ;

Su, J ;

Jen, CL ;

You, SL ;

Lu, SN ;

Huang, GT ;

Iloeje, UH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (01) :65-73

[7] Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma [J].

Chen, GG ;

Li, MY ;

Ho, RLK ;

Chak, ECW ;

Lau, WY ;

Lai, PBS .

JOURNAL OF CLINICAL VIROLOGY, 2005, 34 (01) :7-12

[8] Hepatitis B viral X protein alters the biological features and expressions of DNA repair enzymes in LO2 cells [J].

Cheng, Bin ;

Zheng, Yaochu ;

Guo, Xiaorong ;

Wang, Ying ;

Liu, Chunyan .

LIVER INTERNATIONAL, 2010, 30 (02) :319-326

[9] Hot-spot mutations in hepatitis B virus X gene in hepatocellular carcinoma [J].

Chu, CHC ;

Hao, YW ;

Tabor, E .

LANCET, 1996, 348 (9027) :625-626

[10] Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18 [J].

Du, Yumei ;

Kong, Guangyao ;

You, Xiaona ;

Zhang, Shuai ;

Zhang, Tao ;

Gao, Yuen ;

Ye, Lihong ;

Zhang, Xiaodong .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (31) :26302-26311

← 1 2 3 4 5 6 7 →