Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide

被引：13

作者：

Cao, Maohong ^{[1
]}

Xu, Wei ^{[1
]}

Yu, Jian ^{[2
]}

Zheng, Heyi ^{[1
]}

Tan, Xiang ^{[1
]}

Li, Lei ^{[1
]}

Rui, Ying ^{[1
]}

Xu, Guangfei ^{[1
]}

Cui, Gang ^{[1
,3
]}

Xu, Jian ^{[1
]}

Cao, Jianhua ^{[1
]}

Tao, Tao ^{[1
]}

Ke, Kaifu ^{[1
]}

Wu, Qiyun ^{[1
]}

机构：

[1] Nantong Univ, Dept Neurol, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China

[2] Jinling Hosp, Dept Orthoped, Nanjing 210000, Jiangsu, Peoples R China

[3] Soochow Univ, Dept Neurol, Affiliated Hosp, Suzhou 215000, Jiangsu, Peoples R China

来源：

JOURNAL OF MOLECULAR HISTOLOGY | 2013年 / 44卷 / 05期

基金：

中国国家自然科学基金;

关键词：

SGTB; Lipopolysaccharide (LPS) injection; Neuronal apoptosis; Rat; TPR-CONTAINING PROTEIN; REPEAT-CONTAINING PROTEIN; CYTOCHROME-C; INTERACTS; INVOLVEMENT; MEMORY; HSC70; RATS;

D O I：

10.1007/s10735-013-9517-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SGTB (Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta) plays a critical role in protein-protein interactions. The interaction between SGTB and heat shock cognate protein (Hsc70)/heat shock protein (Hsp70) has aroused much attention in recent years. The present study was designed to elucidate dynamic changes in SGTB expression and distribution in the cerebral cortex in a lipopolysaccharide (LPS)-induced neuroinflammation rat model. It was found that SGTB expression was increased significantly in apoptotic neurons after LPS injection. The result of our in vitro study suggested that SGTB up-regulation might be associated with neuronal apoptosis after H2O2 challenge. In addition, silencing of SGTB in cultured PC12 (Pheochromocytoma) by siRNA indicated that SGTB was required for neuronal apoptosis induced by oxidative stress. Our finding about the cellular signal pathway may provide a new strategy against neuronal apoptosis in neuroinflammation in CNS.

引用

页码：507 / 518

页数：12

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