Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis

被引：40
作者：
Jafarnejad, Seyed Mehdi [1 ]
Ardekani, Gholamreza Safaee [1 ]
Ghaffari, Mazyar [2 ]
Li, Gang [1 ]
机构：
[1] Univ British Columbia, Jack Bell Res Ctr, Dept Dermatol & Skin Sci, Vancouver, BC V6H 3Z6, Canada
[2] Univ British Columbia, Vancouver Gen Hosp, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 15期
基金：
加拿大健康研究院;
关键词：
Cancer; Sox4; Oncogene; Tumor suppressor; BETA-CATENIN EXPRESSION; GLIOMA-INITIATING CELLS; SOX4; EXPRESSION; PROSTATE-CANCER; GENE-EXPRESSION; DIFFERENTIAL EXPRESSION; PROGNOSTIC-SIGNIFICANCE; MELANOCYTE DEVELOPMENT; POSITIVE REGULATOR; BLADDER-CARCINOMA;
D O I：
10.1007/s00018-012-1187-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In addition to their critical roles in embryonic development, cell fate decision, and differentiation, members of Sox (Sry-related high-mobility group box) family of transcription factors including Sox4 have been implicated in various cancers. Multiple studies have revealed an increased expression along with specific oncogenic function of Sox4 in tumors, while others observed a reduced expression of Sox4 in different types of malignancies and suppression of tumor initiation or progression by this protein. More interestingly, the prognostic value of Sox4 is debated due to obvious differences between various reports as well as inconsistencies within specific studies. This review summarizes our current understanding of Sox4 expression pattern and its transcription-dependent, as well as transcription-independent, functions in tumor initiation or progression and its correlation with patient survival. We also discuss the existing discrepancies between different reports and their possible explanations.
引用
收藏
页码：2677 / 2696
页数：20
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