Fluorine-18-labeled fluorine gas for synthesis of tracer molecules

被引：120
作者：
Bergman, J
Solin, O
机构：
[1] ABO AKAD UNIV,TURKU PET CTR,ACCELERATOR LAB,FIN-20500 TURKU,FINLAND
[2] UNIV TURKU,MEDICITY PET RES LAB,TURKU,FINLAND
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 07期
关键词：
fluorine-18; electrophilic fluorine; fluorodestannylation; specific radioactivity; radiopharmaceuticals; PET;
D O I：
10.1016/S0969-8051(97)00078-4
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The aim of this work was to develop a method to produce F-18-labeled fluorine gas ([F-18]F-2) with high specific radioactivity (SA, radioactivity/mass-ratio). F-18-Labeled methyl fluoride ([F-18]CH3F) was synthesized from [F-18]F-aq(-) and mixed with carrier F-2 in an inert neon matrix. The constituents were atomized in an electric discharge, after which a rearrangement and F-18 for F-19 exchange took place. [F-18]F-2 with a specific radioactivity of up to 55 GBq/mu mol is available for the labeling synthesis of tracers for positron emission tomography (PET). (C) 1997 Elsevier Science Inc.
引用
收藏
页码：677 / 683
页数：7
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