The role of noradrenalin in the pathogenesis of primary headaches

被引：7
作者：
Sokolov, A. Y. [1 ,2 ]
Lyubashina, O. A. [1 ]
Amelin, A. V. [3 ]
Panteleev, S. S. [1 ,2 ]
机构：
[1] Russian Acad Sci, IP Pavlov Physiol Inst, St Petersburg 196140, Russia
[2] First Pavlov State Med Univ, Valdman Inst Pharmacol, St Petersburg, Russia
[3] First Pavlov State Med Univ, Dept Neurol & Neurosurg, St Petersburg, Russia
来源：
NEUROCHEMICAL JOURNAL | 2013年 / 7卷 / 04期
关键词：
noradrenalin; adrenoceptors; headache; migraine; trigeminal nerve; endogenous antinociceptive system; ROOT GANGLION NEURONS; FACILITATES INHIBITORY TRANSMISSION; SYMPATHETIC-NERVOUS-SYSTEM; NUCLEUS RAPHE MAGNUS; SPINAL-CORD; SUBSTANTIA-GELATINOSA; PERIAQUEDUCTAL GRAY; CLUSTER HEADACHE; VENTROMEDIAL MEDULLA; POSSIBLE MECHANISM;
D O I：
10.1134/S1819712413040090
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This review is focused on the role of noradrenalin and its receptors in the pathogenesis of primary headaches, in particular, migraine headaches. The data are summarized on the involvement of different adrenoreceptors in the regulation of tone of cerebral vessels and modulation of transmission of nociceptive information in the trigeminovascular system and at the supraspinal level of the CNS. We discuss the pharmacodynamics of several adrenergic drugs that are used for prophylactic treatment of migraine headaches.
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收藏
页码：256 / 265
页数：10
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