Biochemical peculiarities and drug targets in Cryptosporidium parvum:: Lessons from other coccidian parasites

被引：32

作者：

Coombs, GH ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect Immun, Glasgow G12 8QQ, Lanark, Scotland

来源：

PARASITOLOGY TODAY | 1999年 / 15卷 / 08期

关键词：

D O I：

10.1016/S0169-4758(99)01474-X

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

There is an urgent need for effective medicines for treating human and animal cryptosporidiosis. In the absence of drugs being found using an empirical route, the structure-based approach may be the better option for discovering new chemotherapeutic agents against these diseases. With this objective, what possible drug targets are there? Here, Graham Coombs speculates on the best putative targets for chemotherapeutic attack, and reviews what is known and what can be deduced about the biochemical features of Cryptosporidium parvum, the causative agent of cryptosporidiosis, emphasizing the ways in which the parasite differs biochemically front ifs mammalian hosts.

引用

页码：333 / 338

页数：6

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