Lack of HLA-DR2-associated DRB1 gene in a family

被引：1

作者：

Singal, DP

Ye, M

Joseph, S

机构：

[1] Department of Pathology, McMaster University, Hamilton, Ont.

[2] Department of Pathology, McMaster University, Hamilton, Ont. L8N 3Z5

来源：

TISSUE ANTIGENS | 1997年 / 50卷 / 01期

关键词：

HLA-DR; DR2; DRB1; DR2-B1;

D O I：

10.1111/j.1399-0039.1997.tb02842.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-DR51 haplotypes co-express one DRB1 (B1*15 or B1*16) gene and one DRB5 gene. These haplotypes also carry two pseudogenes (DRB6 and DRB9). During routine HLA typing for transplantation, we observed an unexpected DR51 haplotype in two subjects (mother and daughter) in a family. Serological typing showed that these subjects are positive for DR51 and DQ6 but negative for DR15 and DR16. Investigations of genomic DNA by molecular techniques showed that these individuals carry DRB5*0101, DRB6*02 and DQB1*0602 genes, whereas the DRB1 gene associated with either DR15 (B1*1501 to B1*1504) or DR16 (B1*1601 to B1*1606) was not detected in the mother and daughter. It is possible that the new haplotype, DQB1*0602, DRB6*02, DRB5*0101, arose by deletion of DR2-associated DRB1 gene.

引用

页码：85 / 88

页数：4

共 8 条

[1]

BODMER JG, 1995, TISSUE ANTIGENS, V46, P1

[2]

GIPHART MJ, 1992, HLA 1991, P457

[3]

KIMURA A, 1992, HLA 1991, P397

[4] Nomenclature for factors of the HLA system, update June 1996 [J].

Marsh, SGE .

TISSUE ANTIGENS, 1996, 48 (03) :233-234

[5] HLA-DR TYPING BY PCR AMPLIFICATION WITH SEQUENCE-SPECIFIC PRIMERS (PCR-SSP) IN 2 HOURS - AN ALTERNATIVE TO SEROLOGICAL DR TYPING IN CLINICAL-PRACTICE INCLUDING DONOR-RECIPIENT MATCHING IN CADAVERIC TRANSPLANTATION [J].

OLERUP, O ;

ZETTERQUIST, H .

TISSUE ANTIGENS, 1992, 39 (05) :225-235

[6] New HLA-DR haplotypes containing the DRB6 pseudogene [J].

Salazar, M ;

Granja, CB ;

Selvakumar, A ;

Fresia, B ;

Alosco, S ;

Dupont, B ;

Yunis, EJ .

TISSUE ANTIGENS, 1996, 48 (05) :575-579

[7] POLYMORPHISM OF HLA-DR2,DQW1 HAPLOTYPES IN ASIAN INDIANS [J].

SINGAL, DP ;

DSOUZA, M ;

SOOD, SK .

TISSUE ANTIGENS, 1990, 36 (04) :164-170

[8]

TERASAKI PI, 1978, AM J CLIN PATHOL, V69, P103

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