Exosomes in the tumor microenvironment: Promoting cancer progression

被引：48
作者：
Jin, Ye [1 ]
Xing, Jianming [2 ]
Xu, Kejin [1 ]
Liu, Da [1 ,3 ]
Zhuo, Yue [1 ,3 ]
机构：
[1] Changchun Univ Chinese Med, Sch Pharm, Changchun, Peoples R China
[2] Jilin Univ, Sch Life Sci, Changchun, Peoples R China
[3] Changchun Univ Chinese Med, Sch Acupuncture Moxi Bust & Tuina, Changchun, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
exosomes; cancer; tumor microenvironment; metastasis; angiogenesis; immunosuppression; MACROPHAGE POLARIZATION; MESENCHYMAL TRANSITION; EXTRACELLULAR VESICLES; MEDIATED TRANSFER; METASTASIS; CELLS; ANGIOGENESIS; BIOGENESIS; EXPRESSION; LIPIDOMICS;
D O I：
10.3389/fimmu.2022.1025218
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Exosomes, which are extracellular vesicles produced by endosomes, are important performers of intercellular communication functions. For more than three decades, there has been a growing awareness of exosomes as the contents of the tumor microenvironment and their intimate connection to the development of cancer. The composition, generation, and uptake of exosomes as well as their roles in tumor metastasis, angiogenesis, and immunosuppression are discussed in this paper. In order to stop the progression of cancer, it is crucial to find new diagnostic biomarkers and therapeutic targets for the disease. Knowing the biological characteristics of exosomes and their functions in tumor development helps in this endeavor.
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页数：10
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