Exosomes biological significance: A concise review

被引：281
作者：
Johnstone, RM [1 ]
机构：
[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
来源：
BLOOD CELLS MOLECULES AND DISEASES | 2006年 / 36卷 / 02期
关键词：
exosomes; vesicle secretion; cancer therapy;
D O I：
10.1016/j.bcmd.2005.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Exosomes were initially thought to be a mechanism for removing unneeded membrane proteins from reticulocytes. Current Studies have shown that the process of exosome formation extends to many mammalian cells. This concise review highlights the findings reported at a Workshop on Exosomes. Full knowledge of the contribution of exosomes to intercellular information transmission and the potential medical application of this knowledge will depend on the ingenuity of future investigators and their insight into biological processes. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：315 / 321
页数：7
相关论文
共 57 条
[1]   Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis [J].
Abusamra, AJ ;
Zhong, ZH ;
Zheng, XF ;
Li, M ;
Ichim, TE ;
Chin, JL ;
Min, WP .
BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (02) :169-173
[2]  
ADAM M, 1986, THESIS MCGILL U
[3]   Exosome release by reticulocytes -: An integral part of the red blood cell differentiation system [J].
Blanc, L ;
De Gassart, A ;
Géminard, C ;
Bette-Bobillo, P ;
Vidal, M .
BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (01) :21-26
[4]   Exosomes contain ubiquitinated proteins [J].
Buschow, SI ;
Liefhebber, JMP ;
Wubbolts, R ;
Stoorvogel, W .
BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (03) :398-403
[5]   Morphological alteration of fibroblasts mechanically stressed in a collagen lattice [J].
Chamson, A ;
Sudre, F ;
LeGuen, C ;
Le, J ;
Rattner, A ;
Frey, J .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1997, 289 (10) :596-599
[6]   The potential of exosomes in immunotherapy of cancer [J].
Chaput, N ;
Taïeb, J ;
Schartz, N ;
Flament, C ;
Novault, S ;
André, F ;
Zitvogel, L .
BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (02) :111-115
[7]   Exosomes and the MICA-NKG2D system in cancer [J].
Clayton, A ;
Tabi, Z .
BLOOD CELLS MOLECULES AND DISEASES, 2005, 34 (03) :206-213
[8]   Exosome Display technology: Applications to the development of new diagnostics and therapeutics [J].
Delcayre, A ;
Estelles, A ;
Sperinde, J ;
Roulon, T ;
Paz, P ;
Aguilar, B ;
Villanueva, J ;
Khine, S ;
Le Pecq, JB .
BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (02) :158-168
[9]   Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes [J].
Escola, JM ;
Kleijmeer, MJ ;
Stoorvogel, W ;
Griffith, JM ;
Yoshie, O ;
Geuze, HJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20121-20127
[10]   Exosome secretion and red cell maturation:: Exploring molecular components involved in the docking and fusion of multivesicular bodies in K562 cells [J].
Fader, CM ;
Savina, A ;
Sánchez, D ;
Colombo, MI .
BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (02) :153-157
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