New ligands for copper-catalyzed C-N coupling reactions with aryl halides

被引：9

作者：

Chen, Dong ^{[1
,2
]}

Yang, Kai ^{[2
]}

Xiang, Hua ^{[1
]}

Jiang, Sheng ^{[2
]}

机构：

[1] China Pharmaceut Univ, Coll Pharm, Dept Med Chem, Nanjing 210009, Peoples R China

[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 52期

关键词：

C-N coupling reactions; Copper; Cross-coupling; 2-Carbomethoxy-3-hydroxyquinoxaline-di-N-oxide; Ullmann reactions; PHOSPHINE OXIDE LIGAND; HIGHLY EFFICIENT; BOND FORMATION; ROOM-TEMPERATURE; AMINO-ACID; ARYLATION; BROMIDES; IODIDES; AMINATION; MILD;

D O I：

10.1016/j.tetlet.2012.10.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Carbomethoxy-3-hydroxyquinoxaline-di-N-oxide was identified as an efficient novel ligand for the copper-catalyzed coupling reactions of aryl iodides, bromides, and chlorides with aliphatic amines and N-containing heterocycles under mild conditions. The catalytic system showed great functional-group tolerance and excellent chemoselectivity. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7121 / 7124

页数：4

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