Objective Several observational studies have investigated the association between nonsteroidal anti-inflammatory drug (NSAID) use and ovarian cancer risk, but with conflicting results. We performed a systematic review and meta-analysis of the association between NSAID use and ovarian cancer risk. Design Systematic review and meta-analysis of observational studies published until September 2012. Setting Studies were identified from the PubMed database. Population Fourteen case-control and seven cohort studies were included. Methods Pooled relative risks (RRs) with corresponding 95% confidence intervals (CI) for aspirin and non-aspirin NSAIDs, separately, were calculated. Both fixed and random effect models were applied, but only random effect pooled RRs are presented. Risk estimates for invasive and borderline ovarian tumors combined and for invasive ovarian tumors only were calculated. Furthermore, heterogeneity and publication bias were evaluated. Main outcome measures Ovarian cancer. Results In the combined analysis, a slight inverse association between use of aspirin (RR 0.93; 95% CI 0.841.02) and non-aspirin NSAIDs (RR 0.94; 95% CI 0.841.06) and ovarian cancer risk was found, although it was not statistically significant. However, the risk of invasive ovarian cancer was significantly reduced with use of aspirin (RR 0.88; 95% CI 0.790.98). A similar tendency was observed for non-aspirin NSAIDs, but the results were not significant. Conclusions This meta-analysis showed a slight inverse association between NSAIDs and risk of ovarian cancer. However, data suggest that a chemopreventive effect of NSAIDs may be restricted to invasive ovarian tumors. Further research on NSAIDs and ovarian cancer is needed before definite conclusions can be drawn.
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Turnor Ctr ZeTuP, St Gallen, Switzerland
Univ Med Ctr, Dept Hematol & Oncol, Freiburg, GermanyQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Otto, Florian
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Baron, John A.
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Dartmouth Med Sch, Hanover, NH USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Baron, John A.
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Brown, Powel H.
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Baylor Coll Med, Houston, TX 77030 USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Brown, Powel H.
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Burn, John
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Newcastle Univ, Inst Human Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Burn, John
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Greenwald, Peter
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NCI, Canc Prevent Div, NIH, Bethesda, MD 20892 USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Greenwald, Peter
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Jankowski, Janusz
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Univ Oxford, Oxford, England
Queen Mary Univ London, Inst Cellular & Mol Sci, London E1 4NS, EnglandQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Jankowski, Janusz
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La Vecchia, Carlo
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h-index: 0
机构:
Mario Negri Inst Pharmacol Res, Milan, Italy
Univ Milan, Milan, ItalyQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
La Vecchia, Carlo
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Meyskens, Frank
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Univ Calif Irvine, Med Ctr, Chao Family Comprehens Canc Ctr, Orange, CA USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Meyskens, Frank
;
Senn, Hans Joerg
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h-index: 0
机构:
Turnor Ctr ZeTuP, St Gallen, Switzerland
Univ Med Ctr, Dept Hematol & Oncol, Freiburg, GermanyQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Senn, Hans Joerg
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Thun, Michael
论文数: 0引用数: 0
h-index: 0
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Amer Canc Soc, Atlanta, GA 30329 USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
机构:
Turnor Ctr ZeTuP, St Gallen, Switzerland
Univ Med Ctr, Dept Hematol & Oncol, Freiburg, GermanyQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Otto, Florian
;
Baron, John A.
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h-index: 0
机构:
Dartmouth Med Sch, Hanover, NH USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Baron, John A.
;
Brown, Powel H.
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h-index: 0
机构:
Baylor Coll Med, Houston, TX 77030 USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Brown, Powel H.
;
Burn, John
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h-index: 0
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Newcastle Univ, Inst Human Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Burn, John
;
Greenwald, Peter
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Canc Prevent Div, NIH, Bethesda, MD 20892 USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Greenwald, Peter
;
Jankowski, Janusz
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Oxford, England
Queen Mary Univ London, Inst Cellular & Mol Sci, London E1 4NS, EnglandQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Jankowski, Janusz
;
La Vecchia, Carlo
论文数: 0引用数: 0
h-index: 0
机构:
Mario Negri Inst Pharmacol Res, Milan, Italy
Univ Milan, Milan, ItalyQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
La Vecchia, Carlo
;
Meyskens, Frank
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Med Ctr, Chao Family Comprehens Canc Ctr, Orange, CA USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Meyskens, Frank
;
Senn, Hans Joerg
论文数: 0引用数: 0
h-index: 0
机构:
Turnor Ctr ZeTuP, St Gallen, Switzerland
Univ Med Ctr, Dept Hematol & Oncol, Freiburg, GermanyQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Senn, Hans Joerg
;
Thun, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Amer Canc Soc, Atlanta, GA 30329 USAQueen Mary Univ London, Canc Res UK Ctr Epidemiol Math & Stat, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, London EC1M 6BQ, England