Dual Heterogeneous Catalysis for a Regioselective Three-Component Synthesis of Bi- and Tri(hetero)arylpyridines

被引：44

作者：

Allais, Christophe ^{[1
]}

Lieby-Muller, Frederic ^{[1
]}

Constantieux, Thierry ^{[1
]}

Rodriguez, Jean ^{[1
]}

机构：

[1] Aix Marseille Univ, UMR CNRS iSm2 7313, F-13397 Marseille, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 13期

关键词：

biaryls; 1; 3-; 2-dicarbonyls; dual heterogeneous catalysis; multicomponent recations; pyridines; ONE-POT SYNTHESIS; C-H ARYLATION; MULTICOMPONENT DOMINO REACTION; HIGHLY EFFICIENT ACCESS; ENANTIOSELECTIVE SYNTHESIS; POLYSUBSTITUTED PYRIDINES; 1,3-DICARBONYL COMPOUNDS; SUBSTITUTED PYRIDINES; CONJUGATE ADDITION; COUPLING REACTIONS;

D O I：

10.1002/adsc.201200412

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have designed a new, user-friendly oxidative dual heterogeneous catalytic system capable of promoting polysubstituted pyridines as unique products from simple activated Michael acceptors, 1,3-dicarbonyls and ammonium acetate. This metal-free environmentally-respectful and totally regioselective domino reaction proved to be a great strategy to access bi- and triaryl-type pyridines as well as challenging bi- and triheteroaryl-type pyridines in a single operation.

引用

页码：2537 / 2544

页数：8

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