Electrochemical synthesis of isocyanides and 1,n-diisocyanides

被引：0
|
作者：
Hess, U
Brosig, H
Komenda, J
机构：
[1] Humboldt Univ, Inst Pharmazie, Berlin, Germany
[2] Masaryk Univ, Inst Theoret & Phys Chem, CS-60177 Brno, Czech Republic
来源：
PHARMAZIE | 1999年 / 54卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some isocyanide structures have shown fungicide, antibiotic, insecticide, akarizide and other biological activities. Electrochemical reduction of substituted tosylmethylisocyanides (TosMICs) in acetonitrile/0,1 M tetraalkylammonium supporting-electrolyte at Hg-electrodes led to new alkyl-, aryl and 1,n-diisocyanides in good yields. The reaction proceeds in a two-electron C,S-cleavage, reducing exclusively the tosyl-function. The high selectivity of the corresponding ECE-mechanism is supported by quantum-chemical calculation.
引用
收藏
页码：412 / 417
页数：6
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