A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification

被引：29

作者：

Pallares, Roger M. ^{[1
,2
]}

Kong, Say Li ^{[3
]}

Ru, Tan Hui ^{[2
]}

Thanh, Nguyen T. K. ^{[4
,5
]}

Lu, Yi ^{[6
]}

Su, Xiaodi ^{[2
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

[2] ASTAR, Inst Mat Res & Engn, Singapore 117602, Singapore

[3] ASTAR, Genome Inst Singapore, Singapore 138672, Singapore

[4] UCL, Biophys Grp, Dept Phys & Astron, London WC1E 6BT, England

[5] UCL, Healthcare Biomagnet & Nanomat Labs, London W1S 4BS, England

[6] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 77期

基金：

英国工程与自然科学研究理事会;

关键词：

PROSTATE-CANCER; GOLD NANORODS; METHYLATION; BIOMARKERS; GROWTH; ELISA; FLUID; TOOL;

D O I：

10.1039/c5cc05331e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A plasmonic nanosensor (using gold nanorods) with inverse sensitivity is presented for circulating cell-free DNA quantification. The inverse sensitivity (i.e. the lower the analyte concentration, the higher the response intensity) is achieved by the unusual DNA concentration-dependent gold nanorod aggregation. This assay method can adjust the dynamic range by controlling the concentration of nanoparticles in solution.

引用

页码：14524 / 14527

页数：4