Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile

被引：51

作者：

Aguayo, Francisco ^{[1
]}

Khan, Noureen ^{[2
]}

Koriyama, Chihaya ^{[2
]}

Gonzalez, Carolina ^{[1
]}

Ampuero, Sandra ^{[1
]}

Padilla, Oslando ^{[3
]}

Solis, Luisa ^{[4
]}

Eizuru, Yoshito ^{[5
]}

Corvalan, Alejandro ^{[6
]}

Akiba, Suminori ^{[2
]}

机构：

[1] Univ Chile, Virol Program, ICBM, Fac Med, Santiago 8389100, Chile

[2] Kagoshima Univ, Dept Publ Hlth, Grad Sch Med & Dent Sci, Kagoshima 8908544, Japan

[3] Pontificia Univ Catolica Chile, Dept Publ Heath, Fac Med, Santiago, Chile

[4] Pontificia Univ Catolica Chile, Pathol Dept, Fac Med, Santiago, Chile

[5] Kagoshima Univ, Div Oncogen & Persistent Viruses, Ctr Chron Viral Dis, Grad Sch Med & Dent Sci, Kagoshima 8908544, Japan

[6] Pontificia Univ Catolica Chile, Dept Hematol & Oncol, Santiago 133202, Chile

来源：

INFECTIOUS AGENTS AND CANCER | 2011年 / 6卷

关键词：

papillomavirus; breast; cancer; HPV; integration; IN-SITU; MEDULLARY CARCINOMA; IDENTIFICATION; HPV; HYBRIDIZATION; ASSOCIATION; INTEGRATION; EXPRESSION; SEQUENCES; TYPE-16;

D O I：

10.1186/1750-9378-6-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined. Results: The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013). Conclusions: The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.

引用

页数：7

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