Synthesis of deuterated dextromethorphan derivatives

被引:5
作者
Bolcskei, Hedvig [1 ]
Mak, Marianna [1 ]
Dravecz, Ferencz [1 ]
Domany, Gyorgy [1 ]
机构
[1] Gedeon Richter Plc, POB 27, H-1475 Budapest 10, Hungary
关键词
deuteration; dextromethorphan; dextrorphan; N-demethylation; methylation;
D O I
10.3998/ark.5550190.0009.316
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Dextromethorphan is a widely used NMDA receptor antagonist and sodium channel blocker. Deuterated dextromethorphan and dextrorphan were synthesized via the N-desmethyl-dextromethorphan intermediate for pharmacokinetic study.
引用
收藏
页码:182 / 193
页数:12
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