Synthesis of deuterated dextromethorphan derivatives

被引：5

作者：

Bolcskei, Hedvig ^{[1
]}

Mak, Marianna ^{[1
]}

Dravecz, Ferencz ^{[1
]}

Domany, Gyorgy ^{[1
]}

机构：

[1] Gedeon Richter Plc, POB 27, H-1475 Budapest 10, Hungary

来源：

ARKIVOC | 2008年

关键词：

deuteration; dextromethorphan; dextrorphan; N-demethylation; methylation;

D O I：

10.3998/ark.5550190.0009.316

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dextromethorphan is a widely used NMDA receptor antagonist and sodium channel blocker. Deuterated dextromethorphan and dextrorphan were synthesized via the N-desmethyl-dextromethorphan intermediate for pharmacokinetic study.

引用

页码：182 / 193

页数：12

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