共 65 条
The INO80 chromatin remodeling complex in transcription, replication and repair
被引:146
作者:

Conaway, Ronald C.
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机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA
Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA Stowers Inst Med Res, Kansas City, MO 64110 USA

Conaway, Joan Weliky
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机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA
Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA Stowers Inst Med Res, Kansas City, MO 64110 USA
机构:
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA
基金:
美国国家卫生研究院;
关键词:
ACTIN-RELATED PROTEINS;
UCH37 DEUBIQUITINATING ENZYME;
HOMOLOGOUS RECOMBINATION;
DNA-BINDING;
SACCHAROMYCES-CEREVISIAE;
PROMOTER;
BREAK;
RECRUITMENT;
PROTEASOME;
SWR1;
D O I:
10.1016/j.tibs.2008.10.010
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.
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收藏
页码:71 / 77
页数:7
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