The INO80 chromatin remodeling complex in transcription, replication and repair

被引：143

作者：

Conaway, Ronald C. ^{[1
,2
]}

Conaway, Joan Weliky ^{[1
,2
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ACTIN-RELATED PROTEINS; UCH37 DEUBIQUITINATING ENZYME; HOMOLOGOUS RECOMBINATION; DNA-BINDING; SACCHAROMYCES-CEREVISIAE; PROMOTER; BREAK; RECRUITMENT; PROTEASOME; SWR1;

D O I：

10.1016/j.tibs.2008.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.

引用

页码：71 / 77

页数：7

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