Paradigm Shift in Utilization of Livers from Hepatitis C- Viremic Donors into Hepatitis C Virus-Negative Patients

被引：2

作者：

Martin, Eric F. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Div Digest Hlth & Liver Dis, 1120 Northwest 14th St,Suite 1112, Miami, FL 33136 USA

来源：

CLINICS IN LIVER DISEASE | 2021年 / 25卷 / 01期

关键词：

Hepatitis C virus; Liver transplantation; HCV-positive donor; HCV-viremic donor; HUMAN-IMMUNODEFICIENCY-VIRUS; POSITIVE DONORS; TRANSPLANT RECIPIENTS; ORGAN UTILIZATION; ADVANCED FIBROSIS; NATURAL-HISTORY; RISK DONORS; FOLLOW-UP; INFECTION; SOFOSBUVIR;

D O I：

10.1016/j.cld.2020.08.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded. © 2020 Elsevier Inc.

引用

页码：195 / 207

页数：13

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