The differential interfacial tension hypothesis (DITH): a comprehensive theory for the self-rearrangement of embryonic cells and tissues

被引：213

作者：

Brodland, GW ^{[1
]}

机构：

[1] Univ Waterloo, Dept Civil Engn, Waterloo, ON N2L 3G1, Canada

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2002年 / 124卷 / 02期

关键词：

cell mechanics; cell sorting; cell mixing; checkerboard patterns; tissue engulfment; computer simulations; Finite Element Method (FEM); Differential Interfacial Tension Hypothesis (DITH); Differential Adhesion Hypothesis (DAH);

D O I：

10.1115/1.1449491

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A comprehensive theory, herein named the Differential Interfacial Tension Hypothesis (DITH), for the self-rearrangement of embryonic cells and tissues is presented. These rearrangements include sorting, mixing and formation of checkerboard patterns in heterotypic aggregates of embryonic cells, and total or partial engulfment, separation and dissociation of tissues. This broadly-based theory accounts for the action of all currently known cytoskeletal components and cell adhesion mechanisms. The theory is used to derive conditions for the cell and tissue rearrangements trained above. Finite element-based computer simulations involving two or more cell types confirm these conditions.

引用

页码：188 / 197

页数：10

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