High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)peroxydisulphate chemiluminescence system in a two-chip device

被引：10

作者：

Al Lawati, Haider A. J. ^{[1
]}

Varma, Gouri B. ^{[1
]}

Suliman, Fakhr Eldin O. ^{[1
]}

机构：

[1] Sultan Qaboos Univ, Coll Sci, Dept Chem, Al Khoud 123, Oman

来源：

LUMINESCENCE | 2013年 / 28卷 / 01期

关键词：

microfluidics; venlafaxine; chemiluminescence; two-chip device; Tris(2; 2-bipyridyl) ruthenium(II); PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; HUMAN PLASMA; O-DESMETHYLVENLAFAXINE; RAPID-DETERMINATION; METABOLITES; VALIDATION; STABILITY; HPLC;

D O I：

10.1002/bio.2334

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2-bipyridyl) ruthenium(II)peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.028.0 mu g/mL. The detection and quantification limits were found to be 0.006 and 0.018 mu g/mL, respectively, while the relative standard deviation (RSD) was <2.0%. The present CL procedure was applied to the determination of VEN in pharmaceutical formulations and serum samples; the recovery levels were in the range 96.5101.2%. The results suggest that the method is unaffected by the presence of common formulation excipients found in these samples. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：44 / 49

页数：6

共 23 条

[1] High throughput method for the analysis of cetrizine hydrochloride in pharmaceutical formulations and in biological fluids using a tris(2,2′-bipyridyl)ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device
Al Lawati, Haider A. J.
Al Gharibi, Eiman
Al Kindy, Salma M. Z.
Suliman, Fakhr Eldin O.
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TALANTA, 2011, 85 (02) : 906 - 912
[2] Photoinduced oxidation of a tris (2,2′-bipyridyl)ruthenium(II)-peroxodisulfate chemiluminescence system for the analysis of mebeverine HCl pharmaceutical formulations and biological fluids using a two-chip device
Al Lawati, Haider A. J.
Al Dahmani, Zeiyana M.
Varma, Gouri B.
Suliman, FakhrEldin O.
LUMINESCENCE, 2014, 29 (03) : 275 - 283
[3] Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(II)-peroxydisulfate chemiluminescence system in a two chip device
Al Lawati, Haider A. J.
Al-Azwani, Mahmood
Varma, Gouri B.
Suliman, Fakhr Eldin O.
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ANALYTICAL METHODS, 2012, 4 (03) : 773 - 779
[4] Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device
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Al Dahmani, Zeiyana M.
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[6] Enhancement of on chip chemiluminescence signal intensity of tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate system for analysis of chlorpheniramine maleate in pharmaceutical formulations
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[7] Determination of flufenamic acid and mefenamic acid in pharmaceutical preparations and biological fluids using flow injection analysis with tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection
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[9] Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2′-bipyridyl)ruthenium(II) Chloride-diperiodatocuprate(III) Reaction
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[10] Flow injection chemiluminescence determination of cephalosporins in pharmaceutical preparations using tris (2,2′-bipyridyl) ruthenium (II)-potassium permanganate system
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