Current Pharmacological Trends on Myricetin

被引:54
作者
Gupta, Gudiya [1 ]
Siddiqui, Mohd Aftab [1 ]
Khan, Mohd Muazzam [1 ]
Ajmal, Mohd [1 ]
Ahsan, Rabiya [1 ]
Rahaman, Md Azizur [2 ]
Ahmad, Md Afroz [1 ]
Arshad, Md [3 ]
Khushtar, Mohammad [1 ]
机构
[1] Integral Univ, Dept Pharmacol, Fac Pharm, Lucknow 226026, Uttar Pradesh, India
[2] Integral Univ, Dept Pharmaceut Chem, Fac Pharm, Lucknow, Uttar Pradesh, India
[3] Aligarh Muslim Univ, Dept Zool, Aligarh, Uttar Pradesh, India
关键词
antioxidants/NO pathways drugs; behavioural pharmacology; toxicology; cardiovascular pharmacology; cancer pharmacology; cancer; CELL-DEATH; FLAVONOIDS; LIPOXYGENASE; SUPPRESSION; INHIBITION; PROTECTION; INJURY;
D O I
10.1055/a-1224-3625
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Myricetin is a member of the group of flavonoids called flavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol Bring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other flavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is sparingly soluble in aqueous buffers. Myricetin shows its various pharmacological activities including antioxidant, anti-amyloidogenic, antibacterial, antiviral, antidiabetic, anticancer, anti-inflammatory, anti-epileptic and anti-ulcer. This review article focuses on pharmacological effects of Myricetin on different diseases such as osteoporotic disorder, anti-inflammatory disorder, alzheimer's disease, anti-epileptic, cancer, cardiac disorder, diabetic metabolic disorder, hepatoprotective disorder and gastro protective disorder.
引用
收藏
页码:448 / 454
页数:7
相关论文
共 58 条
  • [31] Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease
    Ramezani, Matin
    Darbandi, Niloufar
    Khodagholi, Fariba
    Hashemi, Azam
    [J]. NEURAL REGENERATION RESEARCH, 2016, 11 (12) : 1976 - 1980
  • [32] EFFECTS OF FLAVONOIDS ON NONENZYMATIC LIPID-PEROXIDATION - STRUCTURE-ACTIVITY RELATIONSHIP
    RATTY, AK
    DAS, NP
    [J]. BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 1988, 39 (01): : 69 - 79
  • [33] INTERACTION OF FLAVONOIDS WITH 1,1-DIPHENYL-2-PICRYLHYDRAZYL FREE-RADICAL, LIPOSOMAL MEMBRANES AND SOYBEAN LIPOXYGENASE-1
    RATTY, AK
    SUNAMOTO, J
    DAS, NP
    [J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (06) : 989 - 995
  • [34] Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats
    Rehman, Muneeb U.
    Rather, Irfan A.
    [J]. PLANTS-BASEL, 2020, 9 (01):
  • [35] ROBAK J, 1986, POL J PHARMACOL PHAR, V38, P483
  • [36] ROBAK J, 1988, POL J PHARMACOL PHAR, V40, P451
  • [37] FLAVONOIDS ARE SCAVENGERS OF SUPEROXIDE ANIONS
    ROBAK, J
    GRYGLEWSKI, RJ
    [J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) : 837 - 841
  • [38] Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues
    Sato, Mizuho
    Murakami, Kazuma
    Uno, Mayumi
    Nakagawa, Yu
    Katayama, Sumie
    Akagi, Ken-ichi
    Masuda, Yuichi
    Takegoshi, Kiyonori
    Irie, Kazuhiro
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (32) : 23212 - 23224
  • [39] Myricetin: A Dietary Molecule with Diverse Biological Activities
    Semwal, Deepak Kumar
    Semwal, Ruchi Badoni
    Combrinck, Sandra
    Viljoen, Alvaro
    [J]. NUTRIENTS, 2016, 8 (02):
  • [40] PROTECTION BY ALBUMIN AGAINST THE PROOXIDANT ACTIONS OF PHENOLIC DIETARY-COMPONENTS
    SMITH, C
    HALLIWELL, B
    ARUOMA, OI
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 1992, 30 (06) : 483 - 489