What Is the Relevance of Antimicrobial Resistance on the Outcome of Community-Acquired Pneumonia Caused by Streptococcus pneumoniae? (Should Macrolide Monotherapy Be Used for Mild Pneumonia?)

被引：14
作者：
Low, Donald E. [1 ,2 ]
机构：
[1] Univ Hlth Network, Dept Microbiol, Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Toronto, ON M5G 1X5, Canada
来源：
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2013年 / 27卷 / 01期
关键词：
Community-acquired pneumonia; Streptococcus pneumoniae; Antimicrobial resistance; Resistance paradox; Pollyanna phenomenon; Macrolides; beta-lactams; Fluoroquinolones; IN-VITRO RESISTANCE; PNEUMOCOCCAL PNEUMONIA; MYCOPLASMA-PNEUMONIAE; PENICILLIN RESISTANCE; INFECTIOUS-DISEASES; SUSCEPTIBILITY; BACTEREMIA; MORTALITY; SOCIETY; ADULTS;
D O I：
10.1016/j.idc.2012.11.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multidrug-resistant pneumococci continue to increase worldwide. Although there are still questions regarding the relevance of beta-lactam resistance, the recommendation for the use of the macrolides as monotherapy for mild community-acquired pneumonia should be revisited in view of high rates of resistance, the association of clinical failures with low-level and high-level resistance, and the lack of clinical data to support their need for empirical therapy for the atypicals.
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页码：87 / +
页数：12
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