Genes that Control Vaccinia Virus Immunogenicity

被引：19
|
作者：
Shchelkunov, S. N. [1 ,2 ,3 ]
Shchelkunova, G. A. [1 ]
机构：
[1] State Res Ctr Virol & Biotechnol Vector, Koltsov 630559, Novosibirsk Reg, Russia
[2] Russian Acad Sci, Fed Res Ctr Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
[3] Novosibirsk State Univ, Novosibirsk 630090, Russia
来源：
ACTA NATURAE | 2020年 / 12卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
smallpox; vaccination; immunogenicity; protectiveness; immune modulating proteins; ANTIBODY-RESPONSES; POXVIRUS INFECTION; SMALLPOX VACCINE; IMMUNE-RESPONSE; PROTECTION; DELETION; COWPOX; ATTENUATION; VIRULENCE; HORSEPOX;
D O I：
10.32607/actanaturae.10935
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The live smallpox vaccine was a historical first and highly effective vaccine. However, along with high immunogenicity, the vaccinia virus (VACV) caused serious side effects in vaccinees, sometimes with lethal outcomes. Therefore, after global eradication of smallpox, VACV vaccination was stopped. For this reason, most of the human population worldwide lacks specific immunity against not only smallpox, but also other zoonotic orthopoxviruses. Outbreaks of diseases caused by these viruses have increasingly occurred in humans on different continents. However, use of the classical live VACV vaccine for prevention against these diseases is unacceptable because of potential serious side effects, especially in individuals with suppressed immunity or immunodeficiency (e.g., HIV-infected patients). Therefore, highly attenuated VACV variants that preserve their immunogenicity are needed. This review discusses current ideas about the development of a humoral and cellular immune response to orthopoxvirus infection/vaccination and describes genetic engineering approaches that could be utilized to generate safe and highly immunogenic live VACV vaccines.
引用
收藏
页码：33 / 41
页数：9
相关论文
共 50 条
  • [1] Effect of the Route of Administration of the Vaccinia Virus Strain LIVP to Mice on Its Virulence and Immunogenicity
    Shchelkunov, Sergei N.
    Yakubitskiy, Stanislav N.
    Sergeev, Alexander A.
    Kabanov, Alexei S.
    Bauer, Tatiana, V
    Bulychev, Leonid E.
    Pyankov, Stepan A.
    VIRUSES-BASEL, 2020, 12 (08):
  • [2] Mutations in the A34R gene increase the immunogenicity of vaccinia virus
    Shchelkunov, S. N.
    Bauer, T., V
    Yakubitskiy, S. N.
    Sergeev, A. A.
    Kabanov, A. S.
    Pyankov, S. A.
    VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII, 2021, 25 (02): : 139 - 146
  • [3] Enhancing the Immunogenicity of Vaccinia Virus
    Shchelkunov, Sergei N.
    Yakubitskiy, Stanislav N.
    Sergeev, Alexander A.
    Starostina, Ekaterina, V
    Titova, Ksenia A.
    Pyankov, Stepan A.
    Shchelkunova, Galina A.
    Borgoyakova, Mariya B.
    Zadorozhny, Alexey M.
    Orlova, Lyubov A.
    Kisakov, Denis N.
    Karpenko, Larisa, I
    VIRUSES-BASEL, 2022, 14 (07):
  • [4] ASSESSING IMMUNOGENICITY AND PROTECTIVENESS OF THE VACCINIA VIRUS LIVP-GFP IN THREE LABORATORY ANIMAL MODELS
    Shchelkunov, S. N.
    Sergeev, A. A.
    Yakubitskiy, S. N.
    Titova, K. A.
    Pyankov, S. A.
    INFEKTSIYA I IMMUNITET, 2021, 11 (06): : 1167 - 1172
  • [5] Deletion of the A35 gene from Modified Vaccinia Virus Ankara increases immunogenicity and isotype switching
    Rehm, Kristina E.
    Roper, Rachel L.
    VACCINE, 2011, 29 (17) : 3276 - 3283
  • [6] An Attenuated and Highly Immunogenic Variant of the Vaccinia Virus
    Shchelkunov, S. N.
    Yakubitskiy, S. N.
    Titova, K. A.
    Pyankov, S. A.
    Shulgina, I. S.
    V. Starostina, E.
    Borgoyakova, M. B.
    Kisakov, D. N.
    Karpenko, L. I.
    Shchelkunova, G. A.
    Sergeev, A. A.
    ACTA NATURAE, 2024, 16 (02): : 82 - 89
  • [7] Glycosylated and Nonglycosylated Complement Control Protein of the Lister Strain of Vaccinia Virus
    Meseda, Clement A.
    Kuhn, Jordan
    Atukorale, Vajini
    Campbell, Joseph
    Weir, Jerry P.
    CLINICAL AND VACCINE IMMUNOLOGY, 2014, 21 (09) : 1330 - 1338
  • [8] Influence of glycosylation and oligomerization of vaccinia virus complement control protein on level and pattern of functional activity and immunogenicity
    Kotwal, Girish J.
    PROTEIN & CELL, 2010, 1 (12) : 1084 - 1092
  • [9] Immunogenicity and virulence of attenuated vaccinia virus Tian Tan encoding HIV-1 muti-epitope genes, p24 and cholera toxin B subunit in mice
    Du, Shouwen
    Wang, Yuhang
    Liu, Cunxia
    Wang, Maopeng
    Zhu, Yilong
    Tan, Peng
    Ren, Dayong
    Li, Xiao
    Tian, Mingyao
    Yin, Ronglan
    Li, Chang
    Jin, Ningyi
    JOURNAL OF VIROLOGICAL METHODS, 2015, 219 : 1 - 9
  • [10] Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators
    Sumner, Rebecca P.
    Ren, Hongwei
    Ferguson, Brian J.
    Smith, Geoffrey L.
    VACCINE, 2016, 34 (40) : 4827 - 4834
12345