Brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF) in genetically defined fear-induced aggression

被引：33
作者：
Ilchibaeva, Tatiana V. [1 ]
Kondaurova, Elena M. [1 ,2 ]
Tsybko, Anton S. [1 ]
Kozhemyakina, Rimma V. [1 ]
Popova, Nina K. [1 ,2 ]
Naumenko, Vladimir S. [1 ,2 ]
机构：
[1] Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Novosibirsk, Russia
[2] Novosibirsk State Univ, Novosibirsk 630090, Russia
来源：
BEHAVIOURAL BRAIN RESEARCH | 2015年 / 290卷
基金：
俄罗斯科学基金会;
关键词：
BDNF expression; BDNF and proBDNF levels; BDNF mRNA level; Genetically defined aggression; Rats; NERVE GROWTH-FACTOR; GENE-EXPRESSION; 5-HT1A RECEPTOR; REDUCED AGGRESSIVENESS; MESSENGER-RNA; BEHAVIOR; HIPPOCAMPAL; DEPRESSION; MOUSE; RATS;
D O I：
10.1016/j.bbr.2015.04.041
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The brain-derived neurotrophic factor (BDNF), its precursor (proBDNF) and BDNF mRNA levels were studied in the brain of wild rats selectively bred for more than 70 generations for either high level or for the lack of affective aggressiveness towards man. Significant increase of BDNF mRNA level in the frontal cortex and increase of BDNF level in the hippocampus of aggressive rats was revealed. In the midbrain and hippocampus of aggressive rats proBDNF level was increased, whereas BDNF/proBDNF ratio was reduced suggesting the prevalence and increased influence of proBDNF in highly aggressive rats. In the frontal cortex, proBDNF level in aggressive rats was decreased. Thus, considerable structure-specific differences in BDNF and proBDNF levels as well as in BDNF gene expression between highly aggressive and nonaggressive rats were shown. The data suggested the implication of BDNF and its precursor proBDNF in the mechanism of aggressiveness and in the creation of either aggressive or nonaggressive phenotype. (C) 2015 Elsevier B.V. All rights reserved.
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页码：45 / 50
页数：6
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