Microstructural characterization and in vitro bioactivity of porous glass-ceramic scaffolds for bone regeneration by synchrotron radiation X-ray microtomography

被引：38
作者：
Renghini, Chiara [1 ,2 ]
Giuliani, Alessandra [2 ]
Mazzoni, Serena [2 ]
Brun, Francesco [3 ,4 ]
Larsson, Emanuel [3 ,4 ]
Baino, Francesco [5 ]
Vitale-Brovarone, Chiara [5 ]
机构：
[1] SOMACIS SpA, R&D Dept, I-60022 Castelfidardo, Italy
[2] Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim Biol & Fis, I-60131 Ancona, Italy
[3] Sincrotrone Trieste SCpA, I-34149 Trieste, Italy
[4] Univ Trieste, Dipartimento Ingn & Architettura, I-34127 Trieste, Italy
[5] Politecn Torino, Appl Sci & Technol Dept DISAT, Inst Mat Phys & Engn, I-10129 Turin, Italy
来源：
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY | 2013年 / 33卷 / 09期
关键词：
X-ray microtomography; Glass-ceramic scaffold; Sponge replication; In vitro bioactivity; Bone tissue engineering; TISSUE SCAFFOLDS; TRABECULAR BONE; 45S5; INTERCONNECTIVITY; QUANTIFICATION; HYDROXYAPATITE; BIOGLASS(R); MORPHOLOGY; ANISOTROPY; BEHAVIOR;
D O I：
10.1016/j.jeurceramsoc.2012.10.016
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body's own regenerative mechanism for patient's anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are carried out on Bioglass (R)- and CEL2-derived scaffolds produced by sponge replication (CEL2 is an experimental glass developed at Politecnico di Torino). Synchrotron radiation X-ray microtomography is used to study the samples 3-D architecture, pores size, shape, distribution and interconnectivity, as well as the growth kinetics on scaffolds struts of a newly formed apatitic phase during in vitro treatment in simulated body fluid, in order to describe from a quantitative viewpoint the bioactive potential of the analyzed biomaterials. An accurate comparison between architectural features and bioactive behaviour of Bioglass (R)- and CEL2-derived scaffolds is presented and discussed. (C) 2012 Elsevier Ltd. All rights reserved.
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页码：1553 / 1565
页数：13
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