Reprogramming of genome function through epigenetic inheritance

被引：310
作者：
Surani, MA
机构：
[1] Univ Cambridge, Wellcome CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[2] Univ Cambridge, Physiol Lab, Cambridge CB2 1QR, England
来源：
NATURE | 2001年 / 414卷 / 6859期
关键词：
D O I：
10.1038/35102186
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Most cells contain the same set of genes and yet they are extremely diverse in appearance and functions. It is the selective expression and repression of genes that determines the specific properties of individual cells. Nevertheless, even when fully differentiated, any cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation of the full repertoire of adult cells from a single original cell of any kind. Mechanisms that regulate this exceptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our ability to manipulate stem cells for therapeutic purposes.
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收藏
页码：122 / 128
页数：7
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