Regioselective synthesis and structures of anti-cancer 20(R)-ginsenoside Rg3 derivatives

被引：5
作者：
Fan, Hong-Yu [1 ,2 ]
机构：
[1] Dalian Fusheng Nat Pharmaceut Dev Co Ltd, Dalian 116600, Peoples R China
[2] Jilin Univ, Dept Pharmacol, Changchun, Jilin, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 14期
关键词：
Anti-cancer; 20(R)-ginsenoside Rg3; regioselective synthesis; INTESTINAL BACTERIA; GINSENOSIDE RG3; LIQUID-CHROMATOGRAPHY; SAPONINS; METASTASIS; INHIBITION; CANCER; ESTERS; ESTERIFICATION; TRANSFORMATION;
D O I：
10.1080/14786419.2019.1569007
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Regioselective synthesis of three novel palmitates of 20(R)-ginsenoside Rg(3) was accomplished via a facile strategy, along with complete assignment of their H-1 and C-13 NMR resonances by 1D and 2D NMR (H-1-H-1 COSY, DEPT 135, HSQC, HMBC, and NOESY) techniques. The derivatives were tested for in vitro anti-proliferative activities against pancreatic cancer PANC-1 cells. Compounds 2, 3, and 4 exhibited more potent activity than did 20(R)-ginsenoside Rg(3).
引用
收藏
页码：1962 / 1970
页数：9
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