Epigenetic Regulation of microRNAs in Gastric Cancer

被引：34
作者：
Ma, Jiaojiao [1 ,2 ]
Hong, Liu [1 ,2 ]
Chen, Zheng [1 ,2 ]
Nie, Yongzhan [1 ,2 ]
Fan, Daiming [1 ,2 ]
机构：
[1] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi, Peoples R China
来源：
DIGESTIVE DISEASES AND SCIENCES | 2014年 / 59卷 / 04期
关键词：
Gastric cancer; microRNA (miRNA); Methylation; CpG islands; DOWN-REGULATION; DNA METHYLATION; SUPPRESSES PROLIFERATION; HELICOBACTER-PYLORI; TUMOR-SUPPRESSOR; UP-REGULATION; EXPRESSION; HYPERMETHYLATION; SOX4; CARCINOMA;
D O I：
10.1007/s10620-013-2939-8
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Gastric cancer is one of the most common cancers and accounts for a large proportion of cancer-related deaths in the world, while the pathogenesis of it is still not clear. Epigenetic changes have been found to participate in the development and progression of gastric cancer. Epigenetic changes involve methylation of cytosines in DNA, modifications of histone, chromatin remodeling, and alterations in the expression of microRNAs. MicroRNAs, a family of small non-coding RNAs, have been demonstrated to participate in many fundamental biological processes including the carcinogenesis of gastric cancer. Previous studies have shown that the downregulation of microRNAs are often caused by the methylation in the CpG islands of microRNA promoters. Here, we have summarized the functions and molecular mechanisms of gastric cancer related methylated microRNAs in gastric carcinogenesis. We further envisage the clinical application of microRNA methylation in the early diagnosis, treatment and prognosis assessment of gastric cancer.
引用
收藏
页码：716 / 723
页数：8
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