Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions

被引：20

作者：

M'hamed, Mohamed Ould ^{[1
]}

Alshammari, Abdulrahman G. ^{[1
]}

Lemine, O. M. ^{[2
]}

机构：

[1] Al Imam Mohammad Ibn Saud Islamic Univ IMSIU, Coll Sci, Dept Chem, Riyadh 11623, Saudi Arabia

[2] Al Imam Mohammad Ibn Saud Islamic Univ IMSIU, Coll Sci, Dept Phys, Riyadh 11623, Saudi Arabia

来源：

APPLIED SCIENCES-BASEL | 2016年 / 6卷 / 12期

关键词：

Biginelli reaction; ball milling; catalyst-free; solvent-free; dihydropyrimine derivatives; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; DIHYDROPYRIMIDINONES; DERIVATIVES; SUBSTANCES; PYRIMIDINE; UREA;

D O I：

10.3390/app6120431

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, green, and efficient approach was used to synthesize 3,4-dihydropyrimidines derivatives. We showed that the application of the planetary ball milling method with a ball-to-reagent weight ratio of 8 for the Biginelli reaction provides 3,4-dihydropyrimidines derivatives with excellent yields (>98%) in a short reaction time from the one-pot, three-component condensation of aldehydes, ethyl acetoacetate, and urea (or thiourea).

引用

页数：6

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