A novel and environmentally benign selective route for Vitamin K3 synthesis

被引：34

作者：

Narayanan, S ^{[1
]}

Murthy, KVVSBSR

Reddy, KM

Premchander, N

机构：

[1] Briza Loop San Ramon 7163, San Ramon, CA 94583 USA

[2] Indian Inst Chem Technol, Dept Inorgan & Phys Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

APPLIED CATALYSIS A-GENERAL | 2002年 / 228卷 / 1-2期

关键词：

oxidation; 2-methylnaphthalene; acetic acid; hydrogen peroxide; Vitamin K(3);

D O I：

10.1016/S0926-860X(01)00962-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The oxidation of 2-methylnaphthalene was carried out in acetic acid with aqueous hydrogen peroxide. 2-Methyl-1,4naphthoquinone was obtained in a selectivity of nearly :greater than or equal to90% at 100 degreesC for 3 It. The reaction has been studied by varying different parameters like concentration of hydrogen peroxide, strength of acetic acid, molar ratio of 2-methylnaphthalene to hydrogen peroxide, reaction temperature and time. Compared to the conventional preparation of Vitamin K(3), this method could be economical and ecofriendly as the use of mineral acid and chromium salts are avoided. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：161 / 165

页数：5

共 16 条

[1] CATALYTIC-OXIDATION OF PHENOLS TO P-QUINONES WITH THE HYDROGEN-PEROXIDE AND METHYLTRIOXORHENIUM(VII) SYSTEM [J].