Regulatory CD4+CD25+ T cells and macrophages: communication between two regulators of effector T cells

被引：14

作者：

Zhen, Y. ^{[1
,2
]}

Zheng, J. ^{[2
,3
]}

Zhao, Y. ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China

[2] China US Res Ctr Life Sci, Beijing, Peoples R China

[3] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA

来源：

INFLAMMATION RESEARCH | 2008年 / 57卷 / 12期

关键词：

Regulatory T cells; Macrophages; Interaction; Effector T cells;

D O I：

10.1007/s00011-008-7234-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulatory T cells (Tregs) play an essential role in the induction and maintenance of peripheral tolerance as well as prevention of autoimmunity by limiting the strength of the immune response of effector T cells. Macrophages, a heterogeneous population of phagocytes and professional antigen presenting cells (APCs), can also exert suppressive effects on effector T cells to keep the peripheral balance of immunity. The bi-directional interactions of dendritic cells (DCs) and Tregs have been cell studied. However, much less is known about the reciprocal interaction between macrophages and Tregs. In this review, we will discuss recent observations regarding the interplay of these two regulators of immunity.

引用

页码：564 / 570

页数：7

共 50 条

[41] The role of CD4+CD25+ regulatory T cells in Leishmania infection
Belkaid, Y
EXPERT OPINION ON BIOLOGICAL THERAPY, 2003, 3 (06) : 875 - 885
[42] CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue
Ring, Sabine
Schaefer, Stephan C.
Mahnke, Karsten
Lehr, Hans-Anton
Enk, Alexander H.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (11) : 2981 - 2992
[43] Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells
von Allmen, Caroline E.
Schmitz, Nicole
Bauer, Monika
Hinton, Heather J.
Kurrer, Michael O.
Buser, Regula B.
Gwerder, Myriam
Muntwiler, Simone
Sparwasser, Tim
Beerli, Roger R.
Bachmann, Martin F.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (28) : 11673 - 11678
[44] Human CD4+CD25+ cells:: a naturally occurring population of regulatory T cells
Ng, WF
Duggan, PJ
Ponchel, F
Matarese, G
Lombardi, G
Edwards, AD
Isaacs, JD
Lechler, RI
BLOOD, 2001, 98 (09) : 2736 - 2744
[45] Regulation of the NFAT pathway discriminates CD4+CD25+ regulatory T cells from CD4+CD25- helper T cells
Sumpter, Tina L.
Payne, Kyle K.
Wilkes, David S.
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 83 (03) : 708 - 717
[46] STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells
Passerini, Laura
Allan, Sarah E.
Battaglia, Manuela
Di Nunzio, Sara
Alstad, Alicia N.
Levings, Megan K.
Roncarolo, Maria G.
Bacchetta, Rosa
INTERNATIONAL IMMUNOLOGY, 2008, 20 (03) : 421 - 431
[47] Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28- T suppressor cells
Scotto, L
Naiyer, AJ
Galluzzo, S
Rossi, P
Manavalan, JS
Kim-Schulze, S
Fang, JS
Della Favera, R
Cortesini, R
Suciu-Foca, N
HUMAN IMMUNOLOGY, 2004, 65 (11) : 1297 - 1306
[48] Human retinal pigment epithelium-induced CD4+CD25+ regulatory T cells suppress activation of intraocular effector T cells
Horie, Shintaro
Sugita, Sunao
Futagami, Yuri
Yamada, Yukiko
Mochizuki, Manabu
CLINICAL IMMUNOLOGY, 2010, 136 (01) : 83 - 95
[49] CD4-mediated activation of human CD4+CD25+ regulatory T cells
Becker, CG
Wijdenes, J
Schneider, F
Knop, J
Jonuleit, H
EXPERIMENTAL DERMATOLOGY, 2006, 15 (03) : 204 - 204
[50] A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation
Foussat, A
Cottrez, F
Brun, V
Fournier, N
Breittmayer, JP
Groux, H
JOURNAL OF IMMUNOLOGY, 2003, 171 (10): : 5018 - 5026

← 1 2 3 4 5 →