Regulatory CD4+CD25+ T cells and macrophages: communication between two regulators of effector T cells

被引：14
|
作者：
Zhen, Y. [1 ,2 ]
Zheng, J. [2 ,3 ]
Zhao, Y. [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
[2] China US Res Ctr Life Sci, Beijing, Peoples R China
[3] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA
来源：
INFLAMMATION RESEARCH | 2008年 / 57卷 / 12期
关键词：
Regulatory T cells; Macrophages; Interaction; Effector T cells;
D O I：
10.1007/s00011-008-7234-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Regulatory T cells (Tregs) play an essential role in the induction and maintenance of peripheral tolerance as well as prevention of autoimmunity by limiting the strength of the immune response of effector T cells. Macrophages, a heterogeneous population of phagocytes and professional antigen presenting cells (APCs), can also exert suppressive effects on effector T cells to keep the peripheral balance of immunity. The bi-directional interactions of dendritic cells (DCs) and Tregs have been cell studied. However, much less is known about the reciprocal interaction between macrophages and Tregs. In this review, we will discuss recent observations regarding the interplay of these two regulators of immunity.
引用
收藏
页码：564 / 570
页数：7
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