Regulatory CD4+CD25+ T cells and macrophages: communication between two regulators of effector T cells

被引：14
|
作者：
Zhen, Y. [1 ,2 ]
Zheng, J. [2 ,3 ]
Zhao, Y. [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
[2] China US Res Ctr Life Sci, Beijing, Peoples R China
[3] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA
来源：
INFLAMMATION RESEARCH | 2008年 / 57卷 / 12期
关键词：
Regulatory T cells; Macrophages; Interaction; Effector T cells;
D O I：
10.1007/s00011-008-7234-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Regulatory T cells (Tregs) play an essential role in the induction and maintenance of peripheral tolerance as well as prevention of autoimmunity by limiting the strength of the immune response of effector T cells. Macrophages, a heterogeneous population of phagocytes and professional antigen presenting cells (APCs), can also exert suppressive effects on effector T cells to keep the peripheral balance of immunity. The bi-directional interactions of dendritic cells (DCs) and Tregs have been cell studied. However, much less is known about the reciprocal interaction between macrophages and Tregs. In this review, we will discuss recent observations regarding the interplay of these two regulators of immunity.
引用
收藏
页码：564 / 570
页数：7
相关论文
共 50 条
  • [21] Human CD4+CD25+ regulatory T cells and infectious tolerance
    Stassen, M
    Schmitt, E
    Jonuleit, H
    TRANSPLANTATION, 2004, 77 (01) : S23 - S25
  • [22] Proteomic characterization of murine CD4+CD25+ regulatory T cells
    Rovis, F
    Wait, R
    Lee, BBC
    Monk, CR
    Lechler, RI
    Garden, OA
    IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY, 2004, : 79 - 84
  • [23] An essential role for Scurfin in CD4+CD25+ T regulatory cells
    Khattri, R
    Cox, T
    Yasayko, SA
    Ramsdell, F
    NATURE IMMUNOLOGY, 2003, 4 (04) : 337 - 342
  • [24] Regulatory T Cell Properties of Chicken CD4+CD25+ Cells
    Shanmugasundaram, Revathi
    Selvaraj, Ramesh K.
    JOURNAL OF IMMUNOLOGY, 2011, 186 (04): : 1997 - 2002
  • [25] In vivo depletion of CD4+CD25+ regulatory T cells in cats
    Smithberg, S. Rochelle
    Fogle, Jonathan E.
    Mexas, Angela M.
    Reckling, Stacie K.
    Lankford, Susan M.
    Tompkins, Mary B.
    Dean, Gregg A.
    JOURNAL OF IMMUNOLOGICAL METHODS, 2008, 329 (1-2) : 81 - 91
  • [26] Ex vivo expansion of CD4+CD25+ T regulatory cells
    Field, EH
    BLOOD, 2005, 105 (12) : 4542 - 4543
  • [27] An essential role for Scurfin in CD4+CD25+ T regulatory cells
    Roli Khattri
    Tom Cox
    Sue-Ann Yasayko
    Fred Ramsdell
    Nature Immunology, 2003, 4 : 337 - 342
  • [28] Peripheral generation and function of CD4+CD25+ regulatory T cells
    Taams, LS
    Akbar, AN
    CD4-PLUSCD25-PLUS REGULATORY T CELLS: ORIGIN, FUNCTION AND THERAPEUTIC POTENTIAL, 2005, 293 : 115 - 131
  • [29] The Role of CD4+CD25+ T Regulatory Cells in Autoimmune Diseases
    E. Toubi
    Clinical Reviews in Allergy & Immunology, 2008, 34 : 338 - 344
  • [30] Phenotypic characterization of regulatory CD4+CD25+ T cells in rats
    Stephens, LA
    Barclay, AN
    Mason, D
    INTERNATIONAL IMMUNOLOGY, 2004, 16 (02) : 365 - 375
12345