Regulatory CD4+CD25+ T cells and macrophages: communication between two regulators of effector T cells

被引：14
作者：
Zhen, Y. [1 ,2 ]
Zheng, J. [2 ,3 ]
Zhao, Y. [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
[2] China US Res Ctr Life Sci, Beijing, Peoples R China
[3] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA
来源：
INFLAMMATION RESEARCH | 2008年 / 57卷 / 12期
关键词：
Regulatory T cells; Macrophages; Interaction; Effector T cells;
D O I：
10.1007/s00011-008-7234-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Regulatory T cells (Tregs) play an essential role in the induction and maintenance of peripheral tolerance as well as prevention of autoimmunity by limiting the strength of the immune response of effector T cells. Macrophages, a heterogeneous population of phagocytes and professional antigen presenting cells (APCs), can also exert suppressive effects on effector T cells to keep the peripheral balance of immunity. The bi-directional interactions of dendritic cells (DCs) and Tregs have been cell studied. However, much less is known about the reciprocal interaction between macrophages and Tregs. In this review, we will discuss recent observations regarding the interplay of these two regulators of immunity.
引用
收藏
页码：564 / 570
页数：7
相关论文
共 70 条
  • [1] Mechanisms of tolerance induced by TGFβ-treated APC:: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGFβ
    Alard, P
    Clark, SL
    Kosiewicz, MM
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (04) : 1021 - 1030
  • [2] A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1+ macrophages that suppress naive CD4+ T cell proliferation via an IFN-γ and nitric oxide-dependent mechanism
    Atochina, O
    Daly-Engel, T
    Piskorska, D
    McGuire, E
    Harn, DA
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (08) : 4293 - 4302
  • [3] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Belkaid, Y
    Piccirillo, CA
    Mendez, S
    Shevach, EM
    Sacks, DL
    [J]. NATURE, 2002, 420 (6915) : 502 - 507
  • [4] B cells and professional APCs recruit regulatory T cells via CCL4
    Bystry, RS
    Aluvihare, V
    Welch, KA
    Kallikourdis, M
    Betz, AG
    [J]. NATURE IMMUNOLOGY, 2001, 2 (12) : 1126 - 1132
  • [5] Immune changes during acute cold/restraint stress-induced inhibition of host resistance to Listeria
    Cao, L
    Hudson, CA
    Lawrence, DA
    [J]. TOXICOLOGICAL SCIENCES, 2003, 74 (02) : 325 - 334
  • [6] Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: implications for disease regulation
    Columba-Cabezas, S
    Serafini, B
    Ambrosini, E
    Sanchez, M
    Penna, G
    Adorini, L
    Aloisi, F
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2002, 130 (1-2) : 10 - 21
  • [7] Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Curiel, TJ
    Coukos, G
    Zou, LH
    Alvarez, X
    Cheng, P
    Mottram, P
    Evdemon-Hogan, M
    Conejo-Garcia, JR
    Zhang, L
    Burow, M
    Zhu, Y
    Wei, S
    Kryczek, I
    Daniel, B
    Gordon, A
    Myers, L
    Lackner, A
    Disis, ML
    Knutson, KL
    Chen, LP
    Zou, WP
    [J]. NATURE MEDICINE, 2004, 10 (09) : 942 - 949
  • [8] Fenyk-Melody JE, 1998, J IMMUNOL, V160, P2940
  • [9] Gabbai FB, 1997, J IMMUNOL, V159, P6266
  • [10] Regulation of tumour immunity by CD25+ T cells
    Gallimore, A
    Sakaguchi, S
    [J]. IMMUNOLOGY, 2002, 107 (01) : 5 - 9
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