The biology of pediatric acute megakaryoblastic leukemia

被引：102
作者：
Gruber, Tanja A. [1 ,2 ]
Downing, James R. [2 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA
来源：
BLOOD | 2015年 / 126卷 / 08期
关键词：
ACUTE MYELOID-LEUKEMIA; TRANSIENT MYELOPROLIFERATIVE DISORDER; ACUTE MEGAKARYOCYTIC LEUKEMIA; X-LINKED THROMBOCYTOPENIA; SERUM RESPONSE FACTOR; ETS-RELATED GENE; DOWN-SYNDROME; TRANSCRIPTION FACTOR; GATA1; MUTATIONS; COHESIN COMPLEX;
D O I：
10.1182/blood-2015-05-567859
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down syndrome (DS) is characterized by a founding GATA1 mutation that cooperates with trisomy 21, followed by the acquisition of additional somatic mutations. In contrast, non-DS-AMKL is characterized by chimeric oncogenes consisting of genes known to play a role in normal hematopoiesis. CBFA2T3-GLIS2 is the most frequent chimeric oncogene identified to date in this subset of patients and confers a poor prognosis.
引用
收藏
页码：943 / 949
页数：7
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